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. 2021 Apr 28;11:9147. doi: 10.1038/s41598-021-87402-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Spatial heterogeneity in rat hearts with a healed infarct. (A) A map of AP duration at 80% recovery. The zone under the red semi-circle corresponds to the infarct border zone (BZ), with the zone above the semi-circle being non-infarcted zone. Red arrows point to pixels from which sample traces in the (B) panel are extracted. (B) Sample traces from border and non-infarcted zone verifying the prolongation of the APs in the border zone (manifesting both earlier depolarization and later depolarization). The traces were scaled to have a similar amplitude and baseline, facilitating visual comparison. (C) Average activation map in the same recording. (D) Local conduction velocity visualization for panel (C), estimated by Bayly’s method¹⁷, implemented in COSMAS.