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. 2020 Jul 17;52(7):1128–1139. doi: 10.1038/s12276-020-0469-y

Fig. 4. FMT and dietary modification alter the gut microbiota and local SCFA concentration.

Fig. 4

a Principal component analysis (PCA) of fecal samples, fecal exosomes, or lung tissues from different experiments. b The proportions of the Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Cyanobacteria, and Verrucomicrobia phyla in emphysema mice compared with mice with diet modifications. c Family-level pyrosequencing analysis of the microbial composition of feces, fecal exosomes, or lung tissues from mice treated with FMT, dietary modification, or both. d Bacteria-specific relative composition changes throughout all experiments at the family level. Intervention (I) indicated below; 2nd Exp = diet modification, including fat, protein, and fiber diets (n = 18); 3rd Exp = FMT, high-fiber diet, or both (n = 17); 3rd Exp Fecal EV = FMT and high-fiber diet (n = 5). e SCFA analysis in the feces. Area ratio = analyte peak area/internal standard peak area (n = 4 control mice, n = 6 emphysema mice, and n = 6 emphysema mice with both FMT and high-fiber diet). CTL control, E emphysema, I intervention.