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. 2020 Nov 4;52(11):1809–1822. doi: 10.1038/s12276-020-0431-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative morphology of CAFs (scale bar, 200 μm) and immunofluorescence staining identification of CAFs using antibodies against Vimentin, α-SMA, and FAP (scale bar, 100 μm). b Transmission electron microscopy showing exosomes isolated from the CAFs (scale bar, 100 nm). c Nanoparticle tracking analysis of the CAF-derived exosomes (represented as size vs. concentration). d Western blot analysis of the exosome marker CD63 and the Golgi matrix protein GM130 in exosome-enriched conditioned medium.