TABLE 3.
Feature inclusion frequency using LASSO based feature selection for MI (vs. UA).
| Metabolites-only model | Metabolites and risk factor model | |||||
|---|---|---|---|---|---|---|
| Variable | Frequency | Coefficient | Variable | Frequency | Coefficient | |
| 1 | TG (14:0/20:3/22:2) | 200 | 0.16 | Age | 200 | −0.02 |
| 2 | 3-Hydroxy-3-methyl butyric acid | 200 | 0.13 | LVEF | 200 | −0.05 |
| 3 | HexCer(d18:1/22:0) | 200 | 0.08 | HexCer(d18:1/22:1) | 200 | −0.13 |
| 4 | HexCer(d18:1/22:1) | 200 | −0.16 | 3-Hydroxy-3-methyl butyric acid | 200 | 0.19 |
| 5 | PA (36:1) | 200 | −0.17 | CerP (d18:1/20:3) | 199 | −0.08 |
| 6 | PC(O-38:2) | 200 | −0.22 | Cer(d18:1/22:1) | 185 | −0.05 |
| 7 | D-Methionine | 199 | 0.12 | PC (18:2/18:2) | 174 | −0.02 |
| 8 | Deoxycholic acid | 199 | −0.06 | PC (16:0/20:3) | 166 | 0.15 |
| 9 | PC (18:2/18:2) | 199 | −0.12 | HDLC | 149 | −0.04 |
| 10 | HexCer (d18:1/26:1) | 182 | 0.06 | Hypertension | 126 | −0.04 |
| 11 | PC (O-34:2) | 182 | −0.03 | PC (18:2/20:4) | 126 | −0.04 |
| 12 | PC (18:2/20:2) | 182 | −0.07 | PC(O-38:2) | 126 | −0.02 |
| 13 | L-Cystine | 137 | 0.02 | Deoxycholic acid | 126 | −0.01 |
| 14 | TG (14:1/16:1/22:3) | 137 | −0.02 | L-Cystine | 101 | 0.01 |
| 15 | 3-Methylcrotonyl glycine | 104 | 0.02 | D-Methionine | 101 | 0.02 |
| 16 | MG (18:1) | 104 | −0.05 | |||
LASSO based feature selection was performed within a 5-fold cross-validation framework (200 iterations). Variables selected with frequency >100 times and their average coefficient (Coefficient) were indicated. MI, myocardial infarction; PA, phosphatidic acid; MG, monoglyceride, other abbreviations as in Table 4.