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. 2020 Dec 14;52(12):2034–2045. doi: 10.1038/s12276-020-00545-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Photographs of hematoxylin and eosin (H&E) staining of control and BLM-induced mouse lungs treated with spermidine (50 mg/kg/mouse/day) intraperitoneally on days 10–21. Lung samples were collected on day 21. Original magnification, ×100. b Cell counts in bronchoalveolar lavage (BAL) fluid collected on day 21. The total number of cells was counted using a hemocytometer. Differential cell counts in 500 cells isolated from BAL fluid were analyzed with Diff-Quik (n = 8/group). c Masson’s trichrome staining. Original magnification, ×200. d Quantification of lung fibrosis by the Ashcroft score (n = 8/group). The data are expressed as the mean ± standard error of the mean (SEM). e Collagen measurement by the hydroxyproline assay in control and BLM-induced mouse lungs with and without spermidine treatment (n = 8/group). *p < 0.05 vs. the BLM(+)/spermidine(−)group.