Table 1.

A summary of the primary activities of the eukaryotic RFC complex and the three RLCs.

Biochemical and cellular activity	RFC		CTF18-RLC		RAD17 (Rad24)-RLC		ATAD5 (Elg1)-RLC
	Human	Yeasta	Human	Yeast	Human	Yeast	Human	Yeast
PCNA loading	O	O	O	O	X	X	X	X
PCNA unloading	O (weak)b	O (weak)b	X	Xb/Oc	X	X	O	O
Cohesion establishment	Unknown	X	O	O	X	X	X	X
9-1-1 loading	X	X	X	X	O	O	Xb	Xb
Damage checkpoint	Unknownd	Unknownd	Unknown	X	O	O	Xe	Of
Replication checkpoint	Unknownd	Unknownd	Unknown	O	O	X	Unknown	Xf

^aYeast refers to budding yeast Saccharomyces cerevisiae.

^bBased on in vitro data (ref. ^10,11).

^cBased on in vitro data (ref. ¹¹).

^dSince RFC1 is an essential protein.

^eRef. ¹⁶.

^fRef. ¹⁸.