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. 2021 Apr 28;11:9218. doi: 10.1038/s41598-021-87534-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Average codon influence versus Coverage (percent) computed on the 216 circular codes partitioned in 27 equivalence classes of 8 codes each. The points in blue and red correspond to the 27 best and 27 worst codes within their associated equivalence class, respectively. As for the speed of translation (Fig. 3), the coverage is a predictor of codon influence and the best and worst codes within their equivalence class clusterize. The results for 8000 random codes are also shown in light blue and the p-value for the test that the observed correlation is equal to that of random codes is reported.