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. 2021 Apr 28;11:9218. doi: 10.1038/s41598-021-87534-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Rolling coverage (span: 5 codons) computed on the first (left) and last (right) 100 codon positions, averaged over the whole set of 3983 complete coding sequences of E. coli. The blue and red solid lines correspond to code $X_{173}$ and $X_{192}$ , respectively. The dotted lines correspond to the global coverage of the codes over the whole genome.