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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Clin Pharmacol Ther. 2020 Apr 28;108(2):191–200. doi: 10.1002/cpt.1830

Figure 1. Meta-analysis of the effect of CYP2C9 variant alleles on NSAID exposure.

Figure 1.

Sample sizes and reported area under the curve (AUC) data were extracted from clinical pharmacokinetic studies reviewed for this guideline. Results are expressed as the ratio of mean AUC for variant allele carriers to CYP2C9*1/*1 controls. Overall effects of individual drugs were only estimated using a random effects model when three or more studies were available for analysis. References shown in parenthesis and methodological details are provided in the Supplemental Material.