Table 1.
Summary of histology, electrophysiology, ESA and impedance results for the implanted left ear of all mice. Functional data trends are only for electrode 1 where the histology was taken.
| Mouse #, Ear, and Implant # | 7592L1 | 7627L1 | 7628L1 | 7707L1 | 7708L1 | |
|---|---|---|---|---|---|---|
| Age at Implantation (months) |
Profile ↓ |
1.5 | 1.8 | 1.8 | 1.8 | 1.8 |
| Duration of implantation (days) | 29 | 22 | 16 | 46 | 42 | |
|
SGN Density and Range (cells/mm2 |
A | 858 (741 – 949) |
993 (814 – 1200) |
444 (342 – 575) |
928 (723 – 1227) |
621 (426 – 747) |
| B | 1158 (920 – 1377) |
1327 (1171 – 1427) |
796 (621 – 1095) |
1054 (957 – 1235) |
1084 (935 – 1279) |
|
| C | 1452 (1176 – 1761) |
1343 (1257 –1426) |
609 (454 – 788) |
765 (697 – 822) |
1098 (1087 – 1117) |
|
|
Average SGN Density (cells/mm2) |
A-C | 1187 | 1214 | 616 | 950 | 939 |
| IHC Survival | A | high | medium | high | medium | absent |
| B | high | high | low | high | medium | |
| C | medium | high | absent | medium | high | |
| Average IHC Survival | A-C | high | high | low | medium | medium |
| Intrascalar Tissue | A | high density | low density | high density | high density | high density |
| B | high density | absent | high density | absent | absent | |
| C | absent | absent | absent | absent | absent | |
|
ECAP Slope; Pattern Over Time |
NA | NA | NA | Steep; Increasing to a plateau | Shallow; Stable and shallow from the start | |
|
EABR Slope; Pattern Over Time |
NA | Shallow; NA | Steep; NA | Steep; Increasing then decreasing | Shallow; Increasing then decreasing | |
|
ESA Present; Pattern Over Time |
NA | Large peak; NA | Small peak; NA | Large peak; Increasing | Medium peak; Increasing | |
| Impedance | Off scale after 15 DPI | Off scale after 16 DPI | Off scale after day 9 testing | Increasing to day 15, then stable to 42 DPI | Stable from start to 42 DPI |