Table 1.

Sample Characteristics Across Groups

	Case	Control
Samples, n	720	7244
Volume, mean (μL)	326	276
Median (μL)	300	200
Hemolysis, %	6.39	1.58
Mild (%)	4.16	1.06
Marked (%)	2.08	0.42
Gross (%)	0.15	0.10

Cases were defined as infants meeting inclusion criteria, those born 23 to 42 weeks with hypoxic-ischemic encephalopathy admitted for whole-body hypothermia therapy, strokes, seizures, severe hypotonia, and all very low-birth-weight infants (<1500 g). Gestational age-matched controls included infants not meeting the case criteria. Infants with chromosomal abnormalities, genetic syndromes, and major congenital malformations were excluded.