Table 2.
Glycemic Outcomes (Baseline vs. Control-IQ)
| Overall | |||
|---|---|---|---|
| Baseline | CIQ | P | |
| Percent with less than 6% time below 70 mg/dL and less than 40% time above 180 mg/dL | 33% | 83% | 0.031 |
| CGM consensus goal | 8% | 58% | 0.031 |
| % time below 50 mg/dL | 0.2 (0%–0.9%) | 0.2 (0.1%–0.3%) | 0.575 |
| % time below 54 mg/dL | 0.6 (0.1%–1.6%) | 0.3 (0.2%–0.7%) | 0.424 |
| % time below 60 mg/dL | 1.6 (0.3%–2.8%) | 0.7 (0.5%–1.4%) | 0.110 |
| % time below 70 mg/dL | 3.7 (1.5%–6.4%) | 3.2 (1.5%–4.6%) | 0.182 |
| % time between 70 and 140 mg/dL | 41.8 ± 15.9 | 51.5 ± 12.8 | 0.062 |
| % time between 70 and 180 mg/dL | 61.7 ± 16.1 | 71.3 ± 12.5 | 0.016 |
| % time above 180 mg/dL | 34.1 ± 17.3 | 25.7 ± 12.1 | 0.042 |
| % time above 250 mg/dL | 9.7 (6.1%–19.5%) | 4.2 (2.3%–9%) | 0.024 |
| % time above 300 mg/dL | 3.4 (0.6%–5.4%) | 0.6 (0.1%–1.6%) | 0.013 |
| average CGM (mg/dL) | 161.1 ± 28.1 | 147.1 ± 17.7 | 0.054 |
| Glucose variability (CV, %) | 39.1 ± 5.9 | 36.5 ± 3.7 | 0.121 |
| Total insulin (U/day) | 13.1 ± 3.8 | 13.6 ± 4 | 0.155 |
| Total CHO (g/day) | 106.5 ± 31.4 | 128.3 ± 40.8 | 0.019 |
| percent time in closed loop (%) | — | 96.6 (93.6%–98.9%) | |
| Daytime (7 am–11 pm) | |||
| % time below 50 mg/dL | 0 (0%–0.9%) | 0.1 (0%–0.4%) | 0.594 |
| % time below 54 mg/dL | 0.3 (0.1%–1.4%) | 0.3 (0.1%–1%) | 0.859 |
| % time below 60 mg/dL | 0.7 (0.4%–3.6%) | 0.9 (0.5%–2.1%) | 0.286 |
| % time below 70 mg/dL | 3.6 (1.5%–7.2%) | 3.7 (1.9%–5.2%) | 0.530 |
| % time between 70 and 140 mg/dL | 42.8 ± 15 | 49.6 ± 12.5 | 0.115 |
| % time between 70 and 180 mg/dL | 63.7 ± 15.1 | 69 ± 12.3 | 0.121 |
| % time above 180 mg/dL | 31.5 ± 16.5 | 27.3 ± 12.3 | 0.241 |
| % time above 250 mg/dL | 8.6 (1.7%–15%) | 4.3 (2.2%–8.4%) | 0.164 |
| % time above 300 mg/dL | 2.1 (0%–5.5%) | 0.4 (0%–2.3%) | 0.028 |
| Average CGM (mg/dL) | 157.1 ± 28.4 | 148.2 ± 18.4 | 0.173 |
| Glucose variability (CV, %) | 38.7 ± 6.3 | 37.2 ± 4.2 | 0.370 |
| Total insulin (U/day) | 10.6 ± 3 | 11.2 ± 3.3 | 0.115 |
| percent time in closed loop (%) | — | 96 (92.7%–98.6%) | — |
| Overnight (11 pm–7 am) | |||
| % time below 50 mg/dL | 0 (0%–0%) | 0 (0%–0.7%) | 0.173 |
| % time below 54 mg/dL | 0 (0%–1%) | 0 (0%–0.9%) | 0.735 |
| % time below 60 mg/dL | 0.7 (0%–2.2%) | 0 (0%–1.3%) | 0.260 |
| % time below 70 mg/dL | 2.1 (1.4%–4.9%) | 1.3 (0.4%–2.3%) | 0.239 |
| % time between 70 and 140 mg/dL | 39.8 ± 19.9 | 55.3 ± 19.2 | 0.043 |
| % time between 70 and 180 mg/dL | 57.8 ± 19.7 | 75.9 ± 17 | 0.004 |
| % time above 180 mg/dL | 38.9 ± 21.1 | 22.4 ± 16 | 0.010 |
| % time above 250 mg/dL | 11.7 (7.6%–21.4%) | 3.3 (2%–7.2%) | 0.027 |
| % time above 300 mg/dL | 2.1 (0%–6.2%) | 0 (0%–0.4%) | 0.093 |
| average CGM (mg/dL) | 168.3 ± 33.8 | 144.7 ± 22.1 | 0.028 |
| Glucose variability (CV, %) | 37.2 ± 5.8 | 32.7 ± 5.9 | 0.060 |
| Total insulin (U/night) | 2.5 ± 1 | 2.4 ± 0.8 | 0.493 |
| percent time in closed loop (%) | — | 99.7 (90.5%–100%) | — |
CGM, continuous glucose monitor; CHO, carbohydrates; CV, coefficient of variation.