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. 2021 Mar 16;5:248. Originally published 2020 Oct 22. [Version 2] doi: 10.12688/wellcomeopenres.16330.2

Table 4. Elastic Net regression model optimal alpha parameters and performance of proteins associated with change in growth deficits at one-year.

EN Variable Optimal
alpha
r [95% CI] P value
DWAD Exposure protein variables 0.5 0.73 0.62 – 0.82 <0.0001
DMAD Exposure protein variables 0.5 0.72 0.59 – 0.81 <0.0001
DHAD Exposure protein variables 0.5 0.58 0.42 – 0.71 <0.0001

Footnote: Optimal alpha parameter and correlation coefficients for the EN model enumerating the correlation between DWAD, DMAD, and DHAD at one-year and exposure protein variables (untargeted plasma proteome, and targeted cytokine/chemokines, leptin, and sCD14) extracted by the multivariate regularized models.