Table 4. Elastic Net regression model optimal alpha parameters and performance of proteins associated with change in growth deficits at one-year.
| EN Variable | Optimal
alpha |
r | [95% CI] | P value | |
|---|---|---|---|---|---|
| DWAD | Exposure protein variables | 0.5 | 0.73 | 0.62 – 0.82 | <0.0001 |
| DMAD | Exposure protein variables | 0.5 | 0.72 | 0.59 – 0.81 | <0.0001 |
| DHAD | Exposure protein variables | 0.5 | 0.58 | 0.42 – 0.71 | <0.0001 |
Footnote: Optimal alpha parameter and correlation coefficients for the EN model enumerating the correlation between DWAD, DMAD, and DHAD at one-year and exposure protein variables (untargeted plasma proteome, and targeted cytokine/chemokines, leptin, and sCD14) extracted by the multivariate regularized models.