Table 2.
Previously published rat cardiopulmonary bypass and venoarterial ECMO models
| Weight (grams) | Oxygenator | Surface area of oxygenator (m2) | Priming volume of circuit (oxygenator) (mL) | Priming solution | Duration of extracorporeal circulation (hours) | Dosage of heparin | |
|---|---|---|---|---|---|---|---|
| Popovic et al. [21] | 250–300 | Homemade | 0.048–0.064 | 13.7 (11.3) | blood | 3 | N/A |
| Alexander and Al Ani [22] | 250 | Homemade | 0.017 | 12 (4.4) | crystalloid | 6 | 1 mg/kg |
| Grocott et al. [23] | 350–400 | Homemade | 0.33 | 40 (27) | blood | 1 | 150 IU |
| Fabre et al. [24] | 475–550 | Homemade | N/A | 35 (15) | blood | 2 | 500 IU/kg |
| Gourlay et al. [25] | 350–450 | Homemade | 0.05 | 12 (4) | colloid | 1 | 1000 IU/kg |
| Hamamoto et al. [26] | 350–420 | HPO-003 | 0.03 | 9 (3.3) | colloid | 1 | 200 IU/kg |
| Dong et al. [27] | 450–550 | Micro-1 | 0.05 | 16 (3.5) | blood | 1 | 500 IU/kg |
| You et al. [28] | 430–475 | Homemade | 0.02 | 9.5 (2.8) | colloid | 1 | 500 IU/kg |
| Modine et al. [29] | 422.9 ± 32 | Homemade | 0.05 | 10 (4) | colloid | 1 | 500 IU/kg |
| Gunzinger et al. [30] | 400–500 | Homemade | 0.063 | 8 (4) | colloid | 1 | 500 IU/kg |
| Cresce et al. [31] | 250–350 | Homemade | 0.045 | 30 (6.3) | crystalloid | 2 | 500 IU/kg |
| Zhang et al. [32] | 250–300 | Micro-1 | 0.05 | < 12 (3.5) | colloid | 0 | 500 IU/kg |
| Ali et al. [33] | 250–350 | Homemade | N/A | 8 (N/A) | crystalloid | 1 | 100 IU |
| Chang et al. [34] | 450–550 | Micro-1 | 0.05 | 20 (3.5) | crystalloid | 1 | 500 IU |
| Edinger et al. [35] | 350–400 | Micro-1 | 0.05 | 9 (3.5) | colloid | 2 | 250 IU |
| 350–400 | SAMO | 0.05 | 11 (7) | colloid | 2 | 250 IU | |
| Present study | 450–550 | 3D-printed | 0.0015 | 2.5 (0.3) | crystalloid | 8 | 15–50 IU/kg/h |
Data are expressed as mean ± standard deviation [29]
N/A not available, IU international unit