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. 2021 Mar 18;181(1):47–57. doi: 10.1093/toxsci/kfab020

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Figure 4. — Group differences in MRI measurements. Group differences in substantia nigra pars compacta (SNc) transverse relaxation rate (R2*) and diffusion tensor imaging scalars of fractional anisotropy (FA) and mean diffusivity (MD). Subjects were grouped by HFE genotype (HFE^+/+ vs HFE^H63D/+) and history of paraquat exposure (unexposed vs exposed). R2* measurements were compared using 1-way analyses of covariance (ANCOVA) adjusting for “other pesticide/solvent use,” age, and originating study. FA and MD metrics were compared using ANCOVAs adjusting for “other pesticide/solvent use” and age.