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. 2021 Feb 25;181(1):58–67. doi: 10.1093/toxsci/kfab023

Figure 4.

Figure 4.

PXR- and CYP3A4-dependent oxidative stress and ER stress in COBI hepatotoxicity. A, A heatmap of genes related to oxidative stress, ER stress, and cell death in the liver of hPXR/CYP3A4, Pxr-null/CYP3A4, and hPXR/Cyp3a-null mice pretreated with RIF followed by COBI. B, C, Expression of genes (Gpx2 and Cbr3) associated with oxidative stress. D–F, Expression of genes (Bip, Chop, and Atf3) associated with ER stress. G, A TEM image showing ER dilation in the liver of hPXR/CYP3A4 mice pretreated with RIF followed by COBI. N, nucleus. H, I, Expression of genes (Bax and Dr5) associated with cell death. mRNAs were analyzed by qPCR. All data are expressed as mean ± SEM (n = 3–7). Data in control groups are set as 1, respectively. Statistical significance was determined by two-way ANOVA with Tukey’s post hoc test. *p < .05, **p < .01, ***p < .001, ****p < .0001.