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Overview of the NTERM conjugation method. (a) Schematic diagram of NTERM-conjugated ADC. (b) Chemical structure of the aldehyde-tagged MMAF (ald-MMAF). (c) Schematic representation of the NTERM conjugation reaction
NTERM, N-terminal conjugation through amine bond formation by reductive alkylation reaction; ADC, antibody–drug conjugate; MMAF, monomethyl auristatin F.
