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(a) Weight change of rats after administering a single dose of test samples. The numbers of survived animals are indicated on the right. (b) Dose-related hepatotoxicity induced by ADCs. AST and ALT activity in rat serum were assessed at day 5 after ADC administration. Each point denotes the average value obtained from five animals. Box plots denote mean value and 25–75% quartile
ADCs, antibody–drug conjugate; AST, aspartate aminotransferase; ALT, alanine aminotransferase.
