Fig 1. Schematic of nab paclitaxel preparation via a novel method.

First, we dissolved paclitaxel and PEG in ethanol via ultrasound, and ethanol was subsequently evaporated under vacuum to obtain the liquid compound of paclitaxel and PEG. Then, paclitaxel was loaded in HSA powders by adding the liquid compound dropwise to HSA powder while stirring. Thereafter, the mixtures added to PBS under ultrasound, after which nab paclitaxel suspensions emerged. PEG and the residual ethanol in suspensions were removed by dialysis, and nab paclitaxel was finally obtained after freeze drying.