Table 3. Primary pharmacokinetic parameters of paclitaxel in rats after intravenous administration of Taxol, Abraxane, or self-made nanoparticles at a paclitaxel dose of 7mg/kg (n = 5).

Parameters	Taxol	Abraxane	Self-made nanoparticles
Cmax(ng/mL)	2069.3±518.4b	4713.3±743.0a	4437.8±822.2a
T1/2(h)	1.97±0.08b	2.47±0.13a	2.49±0.16 a
AUC0-inf(μg·h/mL)	2.87±1.01b	7.51±1.46 a	8.23±1.06a
CL(L/h)	0.67±0.26	0.24±0.05	0.22±0.03
Vss(L)	1.57±0.76	0.66±0.13	0.57±0.08
MRT(h)	2.30±0.26	2.75±0.05	2.66±0.12

^a p<0.05 compared with Taxol;

^b p<0.05 compared with Abraxane.