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. 2021 Apr 28;16(4):e0250797. doi: 10.1371/journal.pone.0250797

Table 2. Cumulative incidence of COVID-19 hospitalization per million population and percentage reduction in hospitalization rates for immunisation programs with and without relaxation of uptake and supply constraints compared to no vaccination, 2021–2022.

2021 2022 2021–2022
Incidence % Incidence % Incidence %
No vaccine 12,722 ref 14 901 ref 27,622 ref
Immunization program under constraints
Strong supply constraint 12,819 0.8% 9,436 -36.7% 22,053 -20.2%
[11993;13001] [-6;2] [8732;10163] [-41;-32] [21733;22053] [-21;-18]
Weak supply constraint 11,527 -9.4% 5,669 -62.0% 17,932 -35.1%
[11126;12573] [-13;-1] [5195;8659] [-65;-42] [16321;18737] [-41;-27]
Uptake constraint 10,960 -13.9% 5,270 -64.6% 16,626 -39.8%
[9812;11996] [-23;-6] [4932;7392] [-67;-50] [14744;17266] [-47;-33]
Immunization program with relaxed constraints
Relaxed strong supply and uptake constraint 11,630 -8.6% 3,181 -78.7% 14,811 -46.4%
[11294;12444] [-11;-2] [1826;4297] [-88;-71] [13846;14894] [-50;-44]
Weak supply and uptake constraint 9,606 -24.5% 1,702 -88.6% 11,497 -58.4%
[9240;11204] [-27;-12] [1590;2110] [-89;-86] [11053;11497] [-60;-52]

Based on reference scenario for disease characteristics, level of NPI response (second wave threshold), vaccine profile (protection against infections) and NPIs maintained until end of 2022. Incidence is given per million population and the % of variation is calculated in reference to the no vaccine counterfactual. For each scenario, both values for our reference scenario and range are provided. The vaccine efficacy in the reference case is assumed to be 70% ranging from 50% to 90%.