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. 2021 Apr 28;16(4):e0250708. doi: 10.1371/journal.pone.0250708

Table 4. Recurrent pathologic findings by organ/organ-system.

Organ/system Organ Specific Microthrombi Endothelial Injury TE disease Vasculitis Inflammation* H/D compromise
n (%) n (%) n (%) n (%) n (%) n (%) n (%)
Upper airways+ - - - - - 33/33(100) -
Lung DAD*315/342(92.1) 132 (38.6) 61 (17.8) 47 (13.7) 10 (2.9) 21 (6.1) ** 27 (7.9)
GI - 2/83 (2.4) 2 (2.4) - - - 15(18.1)
Liver - - 1/236 (.4) 93 (39.4) - 59 (25.0) 114(48.3)
Heart - - 8/210 (3.8) 45(21.4) - 37 (17.6) -
Kidney - 55/276 (19.9) 1 (0.4) 2 (0.7) - - 147(53.3)
CNS - 20/110 (18.2) - 9 (8.2) - 9 (8.2) 34(30.9)
Hem-Lymph - - - 1/136 (0.7) - 15(11.0) 7 (5.2)
Skin - 13/44 (29.5) 1 (2.3) - 11 (25.0) 15(34.1) -
Placenta - 11/19(57.9) - - - 1 (5.3) -

GI- gastrointestinal, CNS- central nervous system, Hem-lymph- hematolymphoid, DAD- Diffuse alveolar damage, TE- thromboembolic, H/D-hemodynamic. +Trachea, pharynx, bronchial, mucosa.

* Possible cytopathic effect.

** Inflammation not related to Diffuse Alveolar Damage. Highlighted- most common abnormality by organ-system.