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Chemical structures of the hit compounds from the pilot screen. The 12 hits are categorized into five groups (A–E) based on structural features and possible mechanisms of action. Although hits in groups D and E were also identified from a previous screen based on the soluble PIP2 analogue, WH-15, the other hits are unique to the screen based on XY-69. The number in parentheses represents the percentage inhibition of PLC-γ1 (D1165H) by the corresponding hit compound at 10 μM.
