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. 2021 Apr 28;17(4):e1009507. doi: 10.1371/journal.ppat.1009507

Fig 2. Cryo-EM structures.

Fig 2

(A-D) The central cross-sections through the cryo-EM maps of FMDV-OTi-B77 complex (A), FMDV-OTi-F145 complex (B), FMDV-OTi-R50 complex (C) and FMDV-AWH-R50 complex (D) are shown with the icosahedral two-, three- and five-fold axes. Each image in the 480-pixel boxes corresponds to 446 Å in each dimension. Scale bars, 100 Å. (E-H) Rendered images of the FMDV-OTi-B77 complex (E), FMDV-OTi-F145 complex (F), FMDV-OTi-R50 complex (G) and FMDV-AWH-R50 complex (H). Depth cueing with color is used to indicate radius (< 120 Å, blue; 130–150 Å, from cyan to yellow; > 160 Å, red). The icosahedral five- and three-fold axes are represented by pentagons and triangles, respectively. (I-L) Footprints of B77, F145 and R50 on the FMDV surface. The figure shows a 2D projection of the FMDV surface produced using RIVEM. 5-, 3-, and 2-fold icosahedral symmetry axes are marked as pentagons, triangles, and ovals, respectively, on one icosahedral asymmetrical unit. The spherical polar angles (θ, ϕ) define the location on the icosahedral surface. The depictions are radially depth cued from blue (radius = 130 Å) to red (radius = 155 Å). The residues in the scFv footprints are shown in purple.