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. 2021 Apr 28;38(7):1709–1720. doi: 10.1007/s10815-021-02192-3

Fig. 4.

Fig. 4

Differentially expressed genes in ACE2 and TMPRSS2 co-expressing cells in epiblast and trophectoderm cells. a Expression of TMPRSS4, TMPRSS13, CTSB, and CTSL in ACE2─TMPRSS2─ and ACE2+TMPRSS2+ cells of epiblast. b Expression of TMPRSS4, TMPRSS13, CTSB and CTSL in ACE2─TMPRSS2─ and ACE2+TMPRSS2+ cells of trophectoderm. Significantly different (p < 0.05) mean values are marked as *. c Heat map of the distribution of differentially expressed 1985 genes in ACE2- and TMPRSS2-negative (ACE2–TMPRSS2–) and ACE2 and TMPRSS2 co-expressing (ACE2+TMPRSS2+) cells of the epiblast. d Heat map of the distribution of 1453 differentially expressed genes in ACE2–TMPRSS2– and ACE2+TMPRSS2+ trophectoderm cells. In c and d, rows represent genes and columns represent individual cells, presented on a relative color scale. Data were extracted from scRNAseq of the epiblast of developing human embryos [34]; trophectoderm data was extracted from [35]