Table 3.

Evaluation of publication bias by trim-and-fill method.

Parameter	Trim-and-fill	Method	Pooled Est	95% CI		Asymptotic		No. of studies
				Lower	Upper	Z-value	p-value
ORR	Before	Fixed	0.389	0.301	0.477	8.655	<0.001	27
	After	Fixed	0.334	0.251	0.417	7.868	<0.001	35
DCR	Before	Random	0.150	0.097	0.204	5.475	<0.001	24
	After	Random	0.079	0.019	0.0140	2.580	=0.010	34

ORR: overall response rate; DCR: disease control rate.