Figure 1.

Platinum treatments. (a) Chemical structures of the investigated platinum drugs. The shaded parts of the molecules are removed prior to or during adduct formation. (b) Results of colony survival assays of DT40 cells treated with the indicated platinum drugs for 1 h. (c) Results of cytotoxicity assay of TK6 cells treated with the indicated platinum drugs for 1 h. The mean and the standard error of the mean (SEM) of three independent experiments is shown in (b, c); the concentrations chosen for the mutagenesis assays (IC₂₅ and IC₅₀ values) are indicated with dashed lines.