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Treatment concentrations. Typical values from the literature are shown for comparison
| DT40 treatment concentration (µM) | TK6 treatment concentration (µM) | Clinical usage | ||||||
|---|---|---|---|---|---|---|---|---|
| Platinum drug | IC25 | IC50 | IC25 | IC50 | Peak unbound plasma conc. (µM) | Reference | Elimination half-life of free drug in plasma | Reference |
| Cisplatin | 7.5 | 10 | 4 | 6 | 1.3 | (48) | 0.6 h | (45) |
| Carboplatin | 75 | 110 | 60 | 120 | 38.5 | (47) | 2 h | (45) |
| Oxaliplatin | 2.5 | 4.5 | 2 | 4 | 1.2 | (49) | 1.7 h | (46) |
