. 2021 Feb 16;17(4):e20200221. doi: 10.1590/1984-3143-ar2020-0221

Table 2. Impact of 41.0°C exposure on IL6, IL6R and IL6ST levels in COCs during in vitro maturation using multisource nonlinear mixed model regression.

Transcript		Peak Value ^*	Peak Time (hIVM)	Growth Rate**
IL6	38.5°C	0.32 ± 0.03^a	6.44 ± 0.23^a	2.43 ± 0.28^a
	41.0°C	0.33 ± 0.03^a	4.67 ± 0.23^b	1.82 ± 0.22^a
	P-value	P > 0.05	P < 0.001	P > 0.05
	R²	0.67
	SSE	0.41
IL6R	38.5°C	0.01 ± 0.00^a	5.02 ± 1.49^a	6.33 ± 2.01^a
	41.0°C	0.01 ± 0.00^a	5.16 ± 0.70^a	4.42 ± 0.82^a
	P-value	P > 0.05	P > 0.05	P > 0.05
	R²	0.33
	SSE	0.001
IL6ST	38.5°C	2.66 ± 0.19^a	8.29 ± 0.23^a	2.66 ± 0.22^a
	41.0°C	2.77 ± 0.20^a	6.95 ± 0.23^b	2.63 ± 0.23^a
	P-value	P > 0.05	P < 0.01	P > 0.05
	R²	0.69
	SSE	22.7

Peak value: highest obtained level; **Growth rate: Full Width Half Maximum (3 standard deviations from the mid-point at half maximum). ^a,b means differ P < 0.05.