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. 2021 Apr 20;2021:6687212. doi: 10.1155/2021/6687212

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Copyright © 2021 Jiheng Zhan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PD exerts its antiapoptotic effects by activating the Nrf2/ARE pathway. (a) Immunoblot showing levels of Keap1, Nrf2, NQO-1, and HO-1 protein in the neurons of different groups. ^∗P < 0.05 vs. Control; #P < 0.05 vs. OGD; ΔP < 0.05 vs. OGD + PD (15 μM). Then, cells were divided into the Control, OGD/R, OGD/R + PD, and OGD/R + PD + Brusatol groups. (b) Percentage of apoptotic cells as detected by Annexin V-FITC/PI assay. (c) Percentage of TUNEL-positive apoptotic cells. (d) Immunoblot showing Bcl-2, Bax, and c-Caspase-3 protein levels in each group. ^∗P < 0.05 vs. Control; #P < 0.05 vs. OGD; ΔP < 0.05 vs. OGD + PD.