Table 5.
Subgroup analyses of the association between TG/HDL-C and incidence of type 2 diabetes mellitus in the REACTION study.
| Confounding factor | Serum TG/HDL-C quintile | P for trend | P for interaction | ||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | |||
| Age | 0.01 | ||||||
| <60 years | 1 | 1.67 (0.91, 3.07) 0.10 | 2.59 (1.47, 4.56) <0.01 | 3.28 (1.88, 5.70) <0.01 | 4.50 (2.61, 7.75) <0.01 | <0.01 | |
| >60 years | 1 | 0.96 (0.48, 1.92) 0.90 | 0.74 (0.36, 1.54) 0.43 | 1.30 (0.67, 2.54) 0.44 | 1.08 (0.55, 2.12) 0.82 | 0.50 | |
| Sex | 0.53 | ||||||
| Male | 1 | 1.51 (0.69–3.31) 0.30 | 1.48 (0.68–3.22) 0.33 | 1.65 (0.78–3.50) 0.19 | 2.19 (1.05–4.57) 0.04 | 0.03 | |
| Female | 1 | 1.21 (0.69–2.11) 0.50 | 1.75 (1.04–2.96) 0.03 | 2.61 (1.58–4.31) <0.01 | 2.97 (1.81–4.88) <0.01 | <0.01 | |
| BMI | 0.83 | ||||||
| <25 | 1 | 1.43 (0.73–2.79) 0.30 | 1.85 (0.95–3.60) 0.07 | 2.39 (1.22–4.67) 0.01 | 3.71 (1.97–6.99) <0.01 | <0.01 | |
| ≥25 | 1 | 1.26 (0.68–2.35) 0.46 | 1.55 (0.86–2.79) 0.14 | 2.19 (1.25–3.83) 0.01 | 2.40 (1.38–4.18) <0.01 | <0.01 | |
| Family history of T2DM | 0.20 | ||||||
| Yes | 1 | 1.09 (0.50–2.34) 0.8309 | 1.76 (0.87–3.6) 0.1155 | 2.79 (1.42–5.47) 0.0029 | 2.18 (1.09–4.34) 0.0267 | 0.01 | |
| No | 1 | 1.55 (0.88–2.73) 0.1281 | 1.69 (0.97–2.93) 0.0639 | 2.18 (1.28–3.72) 0.0041 | 3.31 (1.98–5.55) <0.0001 | <0.01 | |
Adjusted for age, sex, body mass index, histories of hypertension, tumors, stroke, and coronary heart disease, smoking status, alcohol intake, low-density lipoprotein cholesterol level, strenuous activity, education level, and family histories of T2DM and tumors.