Fig. 1. Intercurrent events and their implications in weight management clinical trials.

CI confidence interval, ETD estimated treatment difference. ^aIntercurrent events are likely to be unbalanced between treatment arms, potentially introducing bias. ^bAdopting other weight-loss medication recorded as concomitant medication during the trial. Non-pharmacological measures could also be considered, e.g., actively engaging in additional weight-loss programs such as joining a gym or commercial weight-loss program, or bariatric surgery.