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. 2021 Apr 28;592(7856):747–755. doi: 10.1038/s41586-020-03040-7

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

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Fig. 5 — a, Hypothesis 1 proposes the receptors evolved by an initial segmental duplication (SD), then a one round of whole-genome duplication (WGD), followed by two segmental duplications in different vertebrate lineages and then by losses (red X) in specific lineages. b, Hypothesis 2 proposes the initial segmental duplication was followed by two rounds of whole-genome duplication and specific losses (X), including in all vertebrates (blue X). Lines connecting genes indicate that they are on the same chromosome in most species. Alignments between sets of genes indicate the closest related paralogues.