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. 2021 Jan 6;592(7856):756–762. doi: 10.1038/s41586-020-03039-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Differences in numbers of TAS2R, OR and V1R genes between platypus and echidna. b, Phylogeny and synteny of the HP gene. Regions are not drawn to scale. c, Synteny conservation of the region surrounding caseins (CSN genes) and the ancestral teeth genes (ODAM, FDCSP, AMTN, AMBN and ENAM). Silhouettes of the human, opossum, koala and frog are from https://www.flaticon.com/. Silhouettes of the platypus and Tasmanian devil are created by S. Werning and the emu silhouette is created by D. Naish (vectorized by T. M. Keesey); all three silhouettes are reproduced under the Creative Commons Attribution 3.0 Unported licence (http://creativecommons.org/licenses/by/3.0/).