Fig. 3.

(1–11)E2 vaccination does not reduce the number of microglial cells around Aβ plaques. a Representative brain section of the hippocampus of 13-month-old 3xTg mice immunized with (1–11)E2 or PBS analyzed by immunohistochemistry for amyloid plaques (6E10) and microglia (Iba1). b The dot plot represents the number of Iba1 + microglia cells within a distance of 20 μm from β-amyloid plaques. Each dot represents one mouse, diamonds and circles represent high and low anti-Aβ responders, as in Fig. 2. No statistically significant difference was observed between (1–11)E2 vaccinated mice and PBS controls