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(1–11)E2 vaccination does not reduce soluble and insoluble Aβ in the brain. Quantification by ELISA of amyloid-β1–40 (a) and amyloid-β1–42 (b) concentration in RIPA, SDS, and FA fractions from 13-month-old 3xTg mice (n = 10) immunized with (1–11)E2 (black column) or PBS (white column). Error bars represents SEM. No statistically significant difference was observed between (1–11)E2 vaccinated mice and PBS controls
