Table 3.
Pharmacokinetic Parameters According to Sex, Mode of Administration and Polymorphisms in the Fasting Study
| Number | AUC0-∞/DW(kg*h*ng/mL*mg) | Cmax/DW(kg*ng/mL*mg) | Tmax(h) | t1/2(h) | Vd/F(L/kg) | CL/F(L/h*kg) | |
|---|---|---|---|---|---|---|---|
| Sex | |||||||
| Female | 18 | 599.43(157.97) | 71.67(15.91) | 2.48(0.39) | 10.53(2.17) | 26.68(7.76) | 1.77(0.42) |
| Male | 49 | 581.64(136.65) | 71.25(21.45) | 2.27(0.39) | 11.06(2.05) | 29.43(10.58) | 1.83(0.51) |
| Mode of administration | |||||||
| A | 34 | 572.93(146.10) | 66.93(17.40) | 2.32(0.42) | 10.99(2.33) | 29.77(11.21) | 1.85(0.47) |
| B | 33 | 600.31(137.81) | 75.92(21.68) | 2.33(0.38) | 10.84(1.83) | 27.58(8.42) | 1.77(0.51) |
| CES1.rs2244613.c.1165.33C.A | |||||||
| GG | 23 | 568.17(136.90) | 66.94(15.69) | 2.39(0.39) | 10.88(2.11) | 29.50(10.74) | 1.87(0.51) |
| GT | 34 | 588.36(161.85) | 73.31(24.22) | 2.28(0.43) | 10.80(2.11) | 28.71(10.44) | 1.83(0.53) |
| TT | 10 | 621.78(55.46) | 75.15(9.82) | 2.34(0.31) | 11.42(2.04) | 26.77(5.90) | 1.62(0.16) |
| CES1.rs8192935.c.257.885T.C | |||||||
| AA | 41 | 560.26(138.88) | 66.47(17.78) | 2.36(0.40) | 10.74(2.20) | 29.82(11.31) | 1.90(0.52) |
| AG | 21 | 617.22(152.53) | 78.08(23.09) | 2.29(0.41) | 10.97(1.86) | 27.11(7.72) | 1.72(0.44) |
| GG | 5 | 671.53(30.54) | 83.29(10.44) | 2.25(0.32) | 12.14(1.94) | 26.00(3.38) | 1.49(0.06) |
| ABCB1.rs1045642.c.3435T.C | |||||||
| GG | 22 | 559.60(138.34) | 67.37(19.39) | 2.31(0.40) | 11.42(2.47) | 32.08(13.23) | 1.92(0.58) |
| AG | 31 | 612.81(163.77) | 76.08(22.75) | 2.35(0.39) | 10.59(1.72) | 26.43(7.02) | 1.75(0.50) |
| AA | 14 | 570.12(76.99) | 67.17(11.34) | 2.29(0.43) | 10.86(2.16) | 28.37(8.46) | 1.78(0.24) |
| ABCB1.rs4148738.c.2482.2236G.A | |||||||
| TT | 20 | 557.03(137.21) | 65.89(19.38) | 2.31(0.41) | 11.54(2.49) | 32.31(12.40) | 1.93(0.58) |
| CT | 31 | 610.05(166.35) | 76.23(22.81) | 2.35(0.40) | 10.44(1.62) | 26.40(8.25) | 1.77(0.52) |
| CC | 16 | 577.37(82.05) | 68.75(12.09) | 2.30(0.41) | 11.07(2.22) | 28.60(8.59) | 1.76(0.24) |
| ABCB1.rs2032582.c.2677T.A.G | |||||||
| AA | 16 | 557.37(82.05) | 68.75(12.09) | 2.30(0.41) | 11.07(2.22) | 28.60(8.59) | 1.76(0.24) |
| AC/AT | 31 | 610.05(166.35) | 76.23(22.81) | 2.35(0.40) | 10.44(1.62) | 26.40(8.25) | 1.77(0.52) |
| CC/CT/TT | 20 | 557.03(137.21) | 65.89(19.38) | 2.31(0.41) | 11.54(2.49) | 32.31(12.40) | 1.93(0.58) |
Notes: Data are shown as mean (SD).