Table 4.
Pharmacokinetic Parameters According to Sex, Mode of Administration and Polymorphisms in the Fed Study
| Number | AUC0-∞/DW(kg*h*ng/mL*mg) | Cmax/DW(kg*ng/mL*mg) | Tmax(h) | t1/2(h) | Vd/F(L/kg) | CL/F(L/h*kg) | |
|---|---|---|---|---|---|---|---|
| Sex | |||||||
| Female | 6 | 416.13(95.34) | 39.11(10.17) | 6.63(2.04) | 8.60(1.22) | 30.38(3.49) | 2.51(0.59) |
| Male | 31 | 555.76(173.21) | 59.69(21.05)* | 4.77(1.28)* | 9.71(1.33) | 28.16(12.81) | 2.01(0.85) |
| Mode of administration | |||||||
| C | 18 | 525.06(195.05) | 55.39(22.24) | 4.97(1.26) | 9.68(1.16) | 30.94(15.64) | 2.22(1.06) |
| D | 19 | 540.75(148.04) | 57.26(20.40) | 5.17(1.82) | 9.39(1.54) | 26.22(5.98) | 1.97(0.51) |
| CES1.rs2244613.c.1165.33C.A | |||||||
| GG | 16 | 508.14(131.22) | 54.01(16.73) | 5.30(1.78) | 9.28(1.22) | 27.90(7.70) | 2.09(0.52) |
| GT | 15 | 527.16(184.66) | 51.85(20.56) | 5.21(1.49) | 9.51(1.06) | 30.02(16.13) | 2.19(1.10) |
| TT | 6 | 614.61(226.94) | 73.83(26.80) | 4.15(0.67) | 10.26(2.19) | 26.39(9.02) | 1.85(0.78) |
| CES1.rs8192935.c.257.885T.C | |||||||
| AA | 22 | 496.51(177.32) | 50.96(18.93) | 5.30(1.56) | 9.18(1.22) | 30.36(14.31) | 2.30(0.98) |
| AG | 11 | 541.84(102.78) | 56.31(17.17) | 5.11(1.68) | 9.67(0.82) | 26.64(5.96) | 1.90(0.34) |
| GG | 4 | 710.44(201.27) | 86.12(20.61)* | 3.78(0.34) | 11.05(2.34)* | 23.52(6.75) | 1.50(0.46) |
| ABCB1.rs1045642.c.3435T.C | |||||||
| GG | 13 | 568.80(165.51) | 66.00(20.12) | 4.25(0.73) | 9.79(1.67) | 26.02(5.77) | 1.88(0.47) |
| AG | 16 | 492.45(183.68) | 47.37(19.48) | 5.66(1.95)* | 9.70(1.25) | 32.70(15.97) | 2.34(1.07) |
| AA | 8 | 556.46(151.83) | 58.62(20.14) | 5.25(1.15) | 8.78(0.73) | 24.21(6.28) | 1.94(0.63) |
| ABCB1.rs4148738.c.2482.2236G.A | |||||||
| TT | 14 | 568.68(159.39) | 62.13(21.00) | 4.41(0.84) | 9.77(1.63) | 25.85(5.32) | 1.87(0.45) |
| CT | 18 | 502.83(193.15) | 51.36(21.53) | 5.58(1.94) | 9.57(1.25) | 31.86(15.58) | 2.32(1.07) |
| CC | 5 | 542.59(105.28) | 58.11(18.65) | 5.10(0.91) | 8.72(0.49) | 23.95(5.19) | 1.90(0.39) |
| ABCB1.rs2032582.c.2677T.A.G | |||||||
| AA | 6 | 504.08(133.29) | 53.20(20.57) | 5.48(1.23) | 8.53(0.64) | 25.81(6.51) | 2.12(0.64) |
| AC/AT | 17 | 514.08(192.92) | 52.70(21.41) | 5.48(1.95) | 9.69(1.19) | 31.67(16.04) | 2.27(1.08) |
| CC/CT/TT | 14 | 568.68(159.39) | 62.13(21.00) | 4.41(0.84) | 9.77(1.63) | 25.85(5.32) | 1.87(0.45) |
Notes: Data are shown as mean (SD). *P< 0.05 after an ANOVA or t-test.