Table 1.
Protocols for metronidazole desensitization in the setting of 5-nitroimidazole hypersensitivity
| Modified Kurohara Protocol14 (PO)a | Pearlman Protocol30 (IV, PO) |
|---|---|
| Dose 1, 0.0025 mg | Dose 1, 0.005 mgb |
| Dose 2, 0.025 mg | Dose 2, 0.015 mg |
| Dose 3, 0.25 mg | Dose 3, 0.05 mg |
| Dose 4, 2.5 mg | Dose 4, 0.15 mg |
| Dose 5, 5 mg | Dose 5, 0.5 mg |
| Dose 6, 10 mg | Dose 6, 1.5 mg |
| Dose 7, 25 mg | Dose 7, 5 mg |
| Dose 8, 50 mg | Dose 8, 15 mg |
| Dose 9, 100 mg | Dose 9, 30 mg |
| Dose 10, 250 mg | Dose 10, 60 mg |
| Dose 11, 500 mg | Dose 11, 125 mg |
| Dose 12, 1000 mg | Dose 12, 250 mgc |
| Dose 13, 500 mg | |
| Dose 14, 2000 mg |
a
PO doses in the Modified Kurohara Protocol are administered 30 minutes apart
b
Start of IV dosing, administered 15-20 minutes apart
c
Start of PO dosing, administered 60 minutes apart
Abbreviations: IV, intravenous; mg, milligram; PO, oral