Table 1.

Role of sEVs cargo in initiation and progression of GC

Type	Contents	Donor cells	Recipient cells	Function	Ref.
protein	CD97	SGC-7901	SGC-7901	Promote cell proliferation and invasion	[45]
protein	FZD10	HGC-27 and N-87	HGC-27 and N-87	Sustain cancer cell proliferation	[53]
protein	UBR2	p53−/−mBMMSC	p53+/+ mBMMSC and MFC	Promote cell proliferation, migration, and stemness	[54]
protein	GKN1	HFE-145	AGS and MKN1	Inhibit gastric tumorigenesis	[55]
protein	TRIM3	Overexpressed MGC-803 and SGC-7901	MGC-803 and SGC-7901	Suppress GC growth	[56]
miRNA	miR-15b-3p	SGC-7901 and BGC-823	SGC-7901 and BGC-823	Enhance tumorigenesis and malignant transformation	[57]
miRNA	miR-221	GC-MSCs	HGC-27	Promote cell proliferation and migration	[58]
miRNA	miR-221	BM-MSCs	BGC-823 and SGC-7901	Enhance cell proliferation, migration, invasion, and adhesion to the matrix	[59]
miRNA	miR-1290	SGC-7901 and AGS	SGC-7901 and AGS	Promote proliferation and invasion	[60]
miRNA	miR-423-5p	SGC-7901 and HGC-27	SGC-7901 and HGC-27	Promote cancer growth	[61]
miRNA	miR-155-5p	GES-1 and AGS	AGS	Promote proliferation and migration	[62]
miRNA	miR-301a-3p	Hypoxia MGC803	MGC803 and MKN45	Promote GC progression	[63]
lncRNA	SPRY4-IT1	BGC-823	MKN-28	Promote cell growth	[64]
lncRNA	ZFAS1	BGC-823 and MGC-803	MKN-28	Enhance cell proliferation and migration	[65]
lncRNA	lncHEIH	HGC-27	GES-1	Promote GC progression	[66]
lncRNA	lnc01559	MSCs	HGC-27 and AGS	Promote GC progression	[67]
circRNA	circNRIP1	BGC-823 and MKN-45	BGC-823 and MKN-45	Promote GC progression	[68]
circRNA	circSHKBP1	BGC-823 and HGC-27	BGC-823 and HCG-27	Promote GC progression	[69]
circRNA	circNHSL1	HGC-27 and AGS	HGC-27 and AGS	Contributes to GC progression	[70]

Abbreviations: mBMMSC mouse bone marrow mesenchymal stem cell, MSC mesenchymal stem cell, HUVECs human umbilical vein endothelial cells, TAM tumor-associated macrophage