Figure 4.

Antibody kinetics in COVID-19. The antibody kinetics show to be highly variable among individuals, but there seems to be a clear correspondence between severe disease, high antibody production and high neutralizing capacity, while the opposite is true with mild disease. Among the different studies, seroconversion appears at around 12 days. A characteristic finding is that there appears to be distinct kinetic profiles for the different antigens against which antibody responses are developed. The most important question which remains unsolved is whether antibody titers persist over time conferring protection, or if, on the contrary, antibody production wanes over time and renders people susceptible to reinfection.