Table 2. Clinical features of LM according to histopathologic diagnosis.
| Variable | Total patients (n=68) | Melanocytic activation (n=49) | Melanocytic proliferation (n=11) | Subungual melanoma (n=8) | p-value |
|---|---|---|---|---|---|
| Location of LM | |||||
| Hand or foot | 0.253 | ||||
| Hand | 53 (77.9) | 36 (73.5) | 9 (81.8) | 8 (100) | |
| Foot | 15 (22.1) | 13 (26.5) | 2 (18.2) | 0 (0) | |
| Right or left | 0.046 | ||||
| Right | 32 (47.1) | 24 (49.0) | 2 (18.2) | 6 (75.0) | |
| Left | 36 (52.9) | 25 (51.0) | 9 (81.8) | 2 (25.0) | |
| Involved digit | - | ||||
| 1st | 26 (38.2) | 18 (36.7) | 4 (36.4) | 4 (50.0) | |
| 2nd | 14 (20.6) | 11 (22.4) | 3 (27.3) | 0 (0) | |
| 3rd | 6 (8.8) | 5 (10.2) | 0 (0) | 1 (12.5) | |
| 4th | 11 (16.2) | 9 (18.4) | 1 (9.1) | 1 (12.5) | |
| 5th | 11 (16.2) | 6 (12.2) | 3 (27.3) | 2 (25.0) | |
| Width of LM (ratio) | 0.21±0.17 | 0.17±0.11 | 0.16±0.13 | 0.49±0.26 | 0.002 |
| Color of LM | 0.050 | ||||
| Monochromic | 36 (52.9) | 28 (57.1) | 7 (63.6) | 1 (12.5) | |
| Heterochromic | 32 (47.1) | 21 (42.9) | 4 (36.4) | 7 (87.5) | |
| Hutchinson sign | 16 (23.5) | 6 (12.2) | 6 (54.5) | 4 (50.0) | 0.002 |
| Border of LM | 0.919 | ||||
| Well defined | 43 (63.2) | 30 (61.2) | 7 (63.6) | 6 (75.0) | |
| Blurred | 25 (36.8) | 19 (38.8) | 4 (36.4) | 2 (25.0) | |
| Nail plate dystrophy | 15 (22.1) | 9 (18.4) | 1 (9.1) | 5 (62.5) | 0.015 |
| Longitudinal ridge | 12 | 7 | 1 | 4 | |
| Split of nail plate | 1 | 0 | 0 | 1 | |
| Nail plate dystrophy | 1 | 1 | 0 | 0 | |
| Horizontal groove | 1 | 1 | 0 | 0 | |
| Recent change of LM* | 21 (30.9) | 13 (26.5) | 3 (27.3) | 5 (62.5) | 0.147 |
| Change of color | 12 | 8 | 3 | 1 | |
| Change of width | 11 | 7 | 0 | 4 | |
| Change of length | 1 | 0 | 0 | 1 |
Values are presented as number (%), mean±standard deviation, or number only. LM: longitudinal melanonychia, -: not available. *The detailed symptoms appeared independently or in combination, the number of ‘recent change of LM’ and the number of detailed symptoms can be different.