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. 2021 Apr 15;11:637186. doi: 10.3389/fonc.2021.637186

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Copyright © 2021 Puzzolo, Del Giudice, Peragine, Mariglia, De Propris, Cappelli, Trentin, Reda, Cuneo, Molica, Piciocchi, Arena, Mauro, Guarini and Foà

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal analysis of the Th2/Th1 ratio from paired PB samples before and during ibrutinib treatment. The intra-individual variations in T-cell production of IL-4 and IFNγ are expressed as Th2/Th1 ratio. Samples at D0, n=71; at D14, n=50; at M8, n=30; at M12, n=25; at M18, n=22; at M24, n=10 (Wilcoxon paired test D14 vs D0, M8 vs D0, M12 vs D0, M18 vs D0, M24 vs D0; *p<0.05).