Table 2.
Comparison of Baseline, Acute Exacerbation and After Exacerbation of Spirometry and Impulse Oscillometry System Raw Values [Median (IQR: 25–75)] (N = 25)
| Parameters | Baseline | At exacerbation | After exacerbation | Pa | Pb |
|---|---|---|---|---|---|
| Spirometry | |||||
| FEV1 | 1.49 (1.13/2.41) | 1.24 (0.78/2.05) | 1.49 (0.99/2.39) | 0.001 | 0.002 |
| FVC | 1.57 (1.29/2.88) | 1.53 (0.85/2.31) | 1.60 (1.24/2.69) | 0.004 | 0.01 |
| FEF25–75 | 1.85 (0.97/2.64) | 1.14 (0.72/2.38) | 1.72 (1.36/2.69) | 0.007 | 0.001 |
| IOS | |||||
| Z5 (kPa/L/s) | 0.87 (0.67/1.11) | 0.95 (0.77/1.24) | 0.76 (0.70/1.08) | 0.02 | 0.003 |
| R5 (kPa/L/s) | 0.81 (0.62/1.05) | 0.93 (0.75/1.15) | 0.74 (0.64/0.93) | 0.03 | 0.002 |
| R10 (kPa/L/s) | 0.68 (0.50/0.84) | 0.76 (0.56/0.88) | 0.65 (0.56/0.74) | 0.23 | 0.01 |
| R15 (kPa/L/s) | 0.60 (0.45/0.80) | 0.68 (0.55/0.76) | 0.59 (0.48/0.69) | 0.47 | 0.28 |
| R20 (kPa/L/s) | 0.60 (0.42/0.76) | 0.58 (0.50/0.70) | 0.55 (0.48/0.69) | 0.82 | 0.35 |
| X5 (kPa/L/s) | −0.26 (−0.37/−0.12) | −0.30 (−0.42/−0.20) | −0.26 (−0.34/−0.15) | 0.03 | 0.003 |
| X10 (kPa/L/s) | −0.16 (−0.24/−0.02) | −0.23 (−0.35/−0.13) | −0.14 (−0.21/−0.06) | 0.001 | 0.002 |
| X15 (kPa/L/s) | −0.10 (−0.18/0.00) | −0.17 (−0.27/−0.08) | −0.09 (−0.14/0.00) | 0.001 | 0.001 |
| X20 (kPa/L/s) | −0.02 (−0.07/0.04) | −0.06 (−0.14/−0.02) | −0.03 (−0.07/0.04) | 0.002 | 0.001 |
| Delta R5–R20 (%) | 25.15 (10.6/36.7) | 35.78 (21.3/46.3) | 25.72 (13.7/34.4) | 0.01 | 0.009 |
| AX (kPa/L) | 2.22 (0.38/3.51) | 3 (1.57/6.07) | 1.85 (0.7/2.6) | 0.001 | 0.001 |
| Fres (L/s) | 20.97 (15.49/23.5) | 22.2 (21.1/29.3) | 21.4 (15.3/23.5) | 0.001 | 0.002 |
a
Comparison between baseline and at exacerbation.
b
Comparison between at exacerbation and after exacerbation.
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; FEF25–75, forced expiratory flow during the middle half of FVC; Z5, the impedance at 5 Hz; R5, the resistance at 5 Hz; R10, the resistance at 10 Hz; R15, the resistance at 15 Hz; R20, the resistance at 20 Hz; X5, the reactance at 5 Hz; X10, the reactance at 10 Hz; X15, the reactance at 15 Hz; X20, the reactance at 20 Hz; AX, reactance area; Fres, resonance frequency; IOS, impulse oscillometry system.