Table 4.
Comparison of Pulmonary Function Tests (Spirometry and Impulse Oscillometry System) in Follow-Up Visits (N = 31)
| First visit | Second visit (3 months) | Third visit (6 months) | Fourth visit (12 months) | P | |
|---|---|---|---|---|---|
| Spirometry, % | |||||
| FEV1 | 67.47 ± 26.40 | 64.05 ± 25.31 | 65.15 ± 24.74 | 64.10 ± 25.58 | 0.26 |
| FVC | 62.73 ± 23.41 | 60.21 ± 22.14 | 63.42 ± 22.29 | 61.52 ± 21.66 | 0.31 |
| FEV1/FVC | 105.84 ± 8.17 | 104.42 ± 10.13 | 100.15 ± 11.41 | 102.21 ± 12.51 | 0.05 |
| FEF25–75 | 70.10 ± 40.12 | 67.36 ± 41.87 | 61.26 ± 34.09 | 63.68 ± 37.74 | 0.07 |
| IOS | |||||
| Z5a, % | 150 (118.8/199.8) | 152.2 (114.7/257.9) | 150.2 (128.3/266.9) | 171.3 (132.1/273.9) | <0.001b |
| R5a, % | 151.6 (120/193.5) | 157.2 (119/235) | 157.7 (132.5/263.2) | 177.7 (133.9/240.7) | <0.001c |
| R10, % | 147.7 ± 47.23 | 162.23 ± 65.59 | 179.88 ± 68 | 191.74 ± 73 | 0.000d |
| R15, % | 131.13 ± 53.34 | 149 ± 55.31 | 165.73 ± 56.77 | 163.5 ± 63.42 | 0.02e |
| R20a, % | 136.9 (117.9/148.2) | 144.2 (108.2/170.2) | 160 (120.9/209.5) | 170.3 (133.8/207.5) | <0.001f |
| X5a, (kPa/L/s) | −0.23 (−0.40/−0.11) | −0.22 (−0.39/−0.11) | −0.17 (−0.32/−0.12) | −0.23 (−0.42/−0.14) | 0.13 |
| X10a, (kPa/L/s) | −0.18 (−0.23/−0.05) | −0.15 (−0.27/−0.05) | −0.12 (−0.28/−0.06) | −0.12 (−0.33/−0.03) | 0.83 |
| X15a, (kPa/L/s) | −0.11 (−0.16/−0.02) | −0.10 (−0.20/−0.03) | −0.07 (−0.20/−0.02) | −0.06 (−0.24/0.00) | 0.85 |
| X20, (kPa/L/s) | −0.02 ± 0.08 | −0.03 ± 0.08 | −0.03 ± 0.09 | −0.04 ± 0.09 | 0.77 |
| AXa, (kPa/L) | 2.39 (0.69/3.3) | 1.85 (0.70/4.26) | 1.45 (0.59/3.83) | 1.7 (0.52/4.73) | 0.77 |
| Fres, (L/s) | 21 ± 6.59 | 21.43 ± 5.97 | 21.21 ± 7 | 20.71 ± 6.83 | 0.73 |
| Delta R5–R20, % | 26.88 ± 13.27 | 28.98 ± 12.39 | 25.17 ± 12.85 | 23.73 ± 13.36 | 0.07 |
| Shwachman–Kulczycki Score | 55 (40/75) | 55 (40/75) | 55 (45/75) | 55 (40/75) | 0.04g |
Paired comparisons with Bonferroni test.
Nonparametric Brunner–Langer model.
Statistically significant difference between the first visit and the third and fourth visits, the second visit and the fourth visit (P < 0.05).
Statistically significant difference between the first visit and the third and fourth visits, the second visit and the fourth visit (P < 0.05).
Statistically significant difference between all visits (P < 0.05).
Statistically significant difference between the first visit and the fourth visit, the second visit and the fourth visit (P < 0.05).
Statistically significant difference between first and third and fourth visits, second and third and fourth visits (P < 0.05).
Statistically significant between the first visit and the third and fourth visit (P < 0.05).
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; FEF25–75, forced expiratory flow during the middle half of FVC; Z5, the impedance at 5 Hz; R5, the resistance at 5 Hz; R10, the resistance at 10 Hz; R15, the resistance at 15 Hz; R20, the resistance at 20 Hz; X5, the reactance at 5 Hz; X10, the reactance at 10 Hz; X15, the reactance at 15 Hz; X20, the reactance at 20 Hz; AX, reactance area; Fres, resonance frequency; IOS, impulse oscillometry system.