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. 2021 Apr 15;12:653803. doi: 10.3389/fimmu.2021.653803

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Copyright © 2021 Tan, Zhang, Liu, Zhang, Liu and Miao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-33-dependent accumulation of Treg cells might mediates pulmonary regeneration during LPS-induced ARDS via TGF-β1 signaling. (A–C) Exogenous IL-33 supplementation did not affect the macrophages, but interfere with neutrophils population in Treg depleted mice after LPS. (A) Schematic sorting of macrophages (CD11b+Ly6c+F4/80+Ly6G−) or neutrophils (CD11b+Ly6c+F4/80−Ly6G+) in the lung suspension. The percentage of (B) macrophages or (C) neutrophils in the lung was detected by flow cytometry. (D) Total cell counts in BALF were evaluated by a hemocytometer. (E) Secretion of cytokine TGF-β1 in BALF. (F) Secretion of cytokine IL-6 in BALF. (G) Secretion of cytokine TNF-α in BALF. For all panels: mean ± S.D. *p ≤ 0.05; **p ≤ 0.01; and ****p ≤ 0.0001 for one-way analysis of variance with the Bonferroni post hoc test for multiple t-tests. A value of p < 0.05 was considered statistically significant. n = 6 mice per group.