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. 2021 Mar 31;24(4):102384. doi: 10.1016/j.isci.2021.102384

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Genes regulated by rotarod training are highly correlated with neurological functions and diseases

(A) Ingenuity Pathway Analysis (IPA) of genes regulated by rotarod training in WT and Tlr7^–/y mouse brains. Both upregulated (red) and downregulated (blue) genes were combined for IPA. The functions of each network are indicated. Black font depicts genes unaffected by rotarod training but that interact with identified differentially expressed genes (DEG).

(B) Overlapping DEG are highly relevant to anxiety. Eighteen and eight genes out of a total of 29 upregulated and 10 downregulated genes, respectively, are associated with anxiety. The related manuscripts and their PMIDs are indicated.

(C) Heatmap of DEG. Color intensity represents relative TPM levels (log2 values) normalized to the WT–RR group. Gene groupings are also indicated. The color-coded bar represents the Z score.