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. 2021 Apr 15;11:638701. doi: 10.3389/fonc.2021.638701

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Copyright © 2021 Yu, Ma, Liu, Zhang, Feng, Wang and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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p62 deficiency mediates the level of AKT/ AMPK/mTOR related pathway. (A) Western blotting analysis the expression of Bax and Bcl-2 in TPC-1 and p62-KO-TPC-1 cells. (B) Western blotting showing the expression of LC3 in groups of DMSO, p62-KO, Baf (Bafilomycin A1) 5µM and Baf 10µM treatment of 12 hours in TPC-1 cells. (C) Western blotting analysis the expression of AKT and mTOR in p62-KO and RAPA (Rapamycin) treatment groups in TPC-1 cells. (D) Western blotting results showing the level of AMPK in p62-KO and starvation of 12 hours condition (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).