Figure 3.

Comparison of immune features between elderly and young patients from TCGA. (A) Overview of age-associated immune features comprising TMB, CYT, neoantigen, aneuploidy, BCR/TCR richness, immune cells, and checkpoints. (B) Differences in molecular biomarkers reported in immunotherapy-related studies, including TMB, CYT, GEP, neoantigen and protein PD-L1, and some potential biomarkers, including aneuploidy, BCR and TCR richness. (C) Differences in mRNA expression level of 34 immune checkpoints, including both stimulatory and inhibitory immune checkpoints. (D) Differences in 6 types of immune cells, including B cell, CD4+ T cell, CD8+ T cell, neutrophil, macrophage, and myeloid dendritic cell. Propensity score with the nearest neighbor method was used for comparison of immune features between the elderly and young. Sample size for each cancer type was displayed in Supplementary Table S3 .