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. 2021 Apr 15;11:637594. doi: 10.3389/fonc.2021.637594

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Copyright © 2021 Carvajal, Gutiérrez, Morselli and Leiva

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The maternal fetal interface and trophoblast cells subtypes. The figure shows the placental cell types required for the early first trimester human placentation as well as the route to migrate and invade the decidua and myometrium. The different trophoblast subtypes are villous cytotrophoblast (CTB), synctiotrophoblast (STB), cell column trophoblast (CCT), extravillous trophoblast (EVT), endovascular EVT (evEVT), interstitial EVT (iEVT), placental giant trophoblast (PGT). The complete description of the process is in the section “Development of the Human Placenta” of the review.